Role of PLK1/NUMB/NOTCH in epithelial-mesenchymal transition in human melanoma
Abstract Polo-like kinase 1 (PLK1), a serine/threonine kinase, is overexpressed in melanoma and its expression has been associated with poor disease prognosis.PLK1 has been shown to interact with NUMB, a NOTCH antagonist.However, the exact role of PLK1, NUMB, and NOTCH signaling in epithelial-mesenchymal transition (EMT) in melanoma progression is